Cannabis causes the munchies, it’s true. Some types of cannabis have a reputation for increasing appetite. The primary psychoactive in the herb, tetrahydrocannabinol (THC), binds to special cell receptors in the brain that trigger the release of the primary hunger hormone, ghrelin.It’s feasible that people who routinely smoke Mary Jane actually become tolerant to it--their bodies get used to it and a lot of its effects are decreased over time. The cannabinoid receptors in their brains, which regulate memory and appetite, initially cause memory problems and a ravenous appetite (a.k.a. the munchies) but then those same receptors become desensitized and the smokers are less likely to overeat, preventing weight gain.

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